AACR: Pot Use Linked to Testis Cancer

Viewing 1 post (of 1 total)
  • Author
  • #2374

    AACR: Pot Use Linked to Testis Cancer
    By Charles Bankhead, Staff Writer, MedPage Today
    Published: April 22, 2010
    Reviewed by Dori F. Zaleznik, MD; Associate Clinical Professor of Medicine, Harvard Medical School, Boston and
    Dorothy Caputo, MA, RN, BC-ADM, CDE, Nurse Planner

    WASHINGTON — Frequent and long-term marijuana use increased the risk of testicular germ-cell cancer as much as threefold, medical records from a large cancer center showed.

    Daily marijuana use tripled the risk of germ-cell cancer, and use for more than 10 years doubled the risk. The association between marijuana and germ-cell cancers was strongest for nonseminoma tumors.

    “The results are consistent with those from an earlier study,” Britton Trabert, PhD, of the National Cancer Institute, said here at the American Association for Cancer Research meeting.

    “We can only speculate about the nature of this association, but one possibility is that exposure to marijuana during puberty might play a role in the development of nonseminoma, which occurs about a decade earlier than seminoma.”

    Investigators did not have information about the age at which the patients began using marijuana, she added.

    Testicular germ-cell tumors account for fewer than 2% of male cancers, but they are the most common form of cancer in younger men, ages 15 to 44. The incidence of testicular germ-cell tumors has been increasing in the U.S. since the 1970s. Potential environmental factors associated with the increase had not been identified.

    One recent study suggested an association between marijuana use and testicular germ-cell tumors (Cancer 2009; 115: 1215-23). Continuing the investigation of that link, Trabert and colleagues performed a case-control study involving patients treated for testicular germ-cell tumors from 1990 to 1994 at M.D. Anderson Cancer Center in Houston.

    The review of medical records identified 187 cases of germ-cell tumors in men ages 15 to 50 at the time of diagnosis. Each patient provided the name of a friend of the same age and race, and 148 friends who agreed to participate in the study served as the control group.

    Participants completed a self-administered questionnaire, which included items related to environmental exposures and history of drug use, the latter disclosed on a detachable, disposable part of the questionnaire to protect privacy.

    The 187 cancer cases comprised 50 seminomas, 95 nonseminomas, and 42 mixed germ-cell tumors.

    Responses to the questionnaires showed that 55% of controls and 49% of the cancer patients had used marijuana at least once.

    When responses were categorized by frequency of marijuana use, 46.1% of the control group and 29.4% of the patients reported a frequency of less than once per day. Daily or more than once daily was reported by 7.1% of the control group and 18.5% of the patients, a difference that translated into an odds ratio of 2.2 (95% CI 1.0 to 5.1).

    A similar proportion of controls and patients reported using marijuana for 10 years or more (11.4% versus 15.9%, OR 1.2, 95% CI 0.6 to 2.8).

    Trabert and colleagues then examined frequency and duration of marijuana use among patients, according to tumor type. A significantly higher proportion of patients with nonseminoma tumors reported daily or more than once-daily marijuana use compared with the control group, 22.3% versus 7.1% (OR 3.1, 95% CI 1.2 to 8.2).

    Patients with seminomas and mixed germ-cell tumors also were more likely to report frequent use (14.3% and 14.6%, respectively), but differences from the control group did not reach statistical significance.

    A similar pattern emerged from the analysis of duration of marijuana use. Trabert reported that 21.5% of patients with nonseminoma used marijuana for 10 years or more, which proved to be significantly higher than in the control group (OR 2.4, 95% CI 1.0 to 6.1).

    About 10% of patients in the other two tumor categories reported using marijuana for 10 years or longer, a proportion that was lower than that of the control group.

    Trabert and her associates did not have information about other clinical or histologic characteristics of the tumors to determine whether marijuana use influenced those factors.

    http://www.medpagetoday.com/MeetingCoverage/AACR/19691?utm_content=GroupCL&utm_medium=email&impressionId=1272011183027&utm_campaign=DailyHeadlines&utm_source=mSpoke&userid=247679″ onclick=”window.open(this.href);return false;

Viewing 1 post (of 1 total)
  • You must be logged in to reply to this topic.
American Preppers Network Forum